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Is pepper spray really necessary to protect against small animals? Common animals such as squirrels, skunks, and rabbits can be quite vicious when infected with rabies. Wildlife may appear tame to humans and nocturnal animals may appear in daylight. After the bite, the virus travels up the nearby nerves to the spinal cord, then the brain. The best reccomendation is to not allow animals to get close enough to bite you. Have your animal pepper spray ready.