When is it right to use pepper spray? You should ONLY use pepper spray if you are threatened or your life is in danger. Please note that it is a crime to use pepper spray to commit malicious acts. Always remember that you assume all risk and liability for owning and using pepper spray. Even if you use it correctly, there is no guarantee that it will always be effective at hindering an attack, and there is always the possibility that it may be used against you instead.