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What is OC Pepper Spray All About? OC is oleoresin capsicum, which is extracted from chili peppers and is commonly called Pepper Spray. This product is the most widely sold today and the spray of choice for police since 1977. OC pepper spray is generally regarded to be the most distressing to experience, but it must be sprayed directly in the eyes or inhaled to be effective. The product is an oily liquid not very soluble in water.